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The iTREAT study will compare different ways of treating asthma: a pill or adding a second inhaler to see if they reduce the need for emergency care or going to the hospital.
Every patient will be given online asthma symptom tracking tools that have been shown to help manage asthma symptoms. Some participants will use a second inhaled medicine with their regular rescue or quick relief medicine. Some will start taking an antibiotic pill. Some will use both. The groups are assigned by chance, like a flip of a coin.
Adults or adolescents with asthma cared for at a participating site:
The study will be a four-arm study with 3,200 people. Study arms will be rescue ICS (use of inhaled corticosteroids as part of rescue therapy), azithromycin therapy, rescue ICS plus azithromycin, or control.
All participants will record their asthma symptoms using online tools.
The primary outcome will be yearly asthma exacerbation rates compared across the three intervention arms to the control arm. Secondary outcomes will be asthma control and asthma quality of life.
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